Nestled in the bustling heart of Shanghai's inner ring, Columbia Circle is a historic site that houses the Columbia Country Club, the former residence of Sun Ke and the Naval Club building complex — all dating back to the 1920s and 30s. 

From the establishment of the People's Republic of China to 2016, this area had served as the office and production site for the Shanghai Institute of Biological Products under China National Pharmaceutical Group Co Ltd. 

It was at this location that the institute embarked on its pioneering mission of vaccine research and development related to national health. The place gave birth to China’s first BCG vaccine, first batch of blood products, first albumin, and first vaccine for the Hu-191 measles virus strain. 

The institute was relocated in 2014 due to strategic adjustments aligning with the evolving demands of the biopharmaceutical industry. In collaboration with the strong support of Changning district government for urban renewal initiatives, efforts were made to repurpose and develop the land and buildings. 

In June 2016, after an open tendering and bidding process, the institute and Shanghai Vanke Real Estate Co Ltd signed a lease and development agreement for the entire plot. The project covers a total area of 48,000 square meters, with approximately 24,000 sq m designated for the first phase and ongoing development slated for the second phase. 

On May 25, 2018, the first phase of the project, now named Columbia Circle, was formally inaugurated after meticulous planning. Today, it stands as a testament to Changning district's commitment to Shanghai’s urban renewal and development philosophy of "warmth, stroll-worthy streets, and architecture full of stories".

The place has evolved into a new urban business district and an all-encompassing, vibrant community integrating office spaces, entertainment, daily life and cultural functions, as well as a popular destination for Shanghai residents and tourists alike.